n 1793, at Frankfurt, Luise met the crown prince of Prussia, afterwards King Frederick William III. Deeply impressed by her beauty and nobility of character, Frederick William asked her to become his wife. They were married on December 24 of the same year. As Queen of Prussia she commanded universal respect and affection, and nothing in Prussian history is more admired than the dignity and unflinching courage with which she bore the sufferings inflicted on her and her family during the war between Prussia and France.

After the battle of Jena she went with her husband to Königsberg, and when the battles of Eylau and Friedland had placed Prussia absolutely at the mercy of France, she made a personal appeal to Napoleon I of France at his headquarters in Tilsit, but without success. Early in 1808 she accompanied the king from Memel to Königsberg, whence, towards the end of the year, she visited Saint Petersburg, returning to Berlin on December 23, 1809.

During the war Napoleon attempted to destroy the queen's reputation, but the only effect of his charges in Prussia was to make her more deeply beloved. On July 19, 1810 she died in her husband's arms, while visiting her father in Strelitz. She was buried in the garden of the palace at Charlottenburg, where a mausoleum, containing a fine recumbent statue by Rauch, was built over her grave. In 1840 her husband was buried by her side.